منابع مشابه
SNARE Zippering and Synaptic Strength
Synapses vary widely in the probability of neurotransmitter release. We tested the hypothesis that the zippered state of the trans-SNARE (Soluble N-ethylmaleimide-sensitive factor Attachment protein REceptor) complex determines initial release probability. We tested this hypothesis at phasic and tonic synapses which differ by 100-1000-fold in neurotransmitter release probability. We injected, p...
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Partial or total isolation of the cerebral cortex was offered as a model for the study of focal epilepsy 6. After weeks or months the isolated cortex became sensitive to electrical stimulation or to topically applied acetylcholine (ACh) 5. Isolated cortex may also sustain prolonged epileptiform afterdischargeg, 2a. This is one measure of supersensitivity. A causal relationship between supersens...
متن کاملAdult-born neurons modify excitatory synaptic transmission to existing neurons
Adult-born neurons are continually produced in the dentate gyrus but it is unclear whether synaptic integration of new neurons affects the pre-existing circuit. Here we investigated how manipulating neurogenesis in adult mice alters excitatory synaptic transmission to mature dentate neurons. Enhancing neurogenesis by conditional deletion of the pro-apoptotic gene Bax in stem cells reduced excit...
متن کاملSleep and Its Effects on Synaptic Strength
Throughout the history of sleep research, many theories have been put forward in an attempt to explain the function of the state of sleep. The most popular and well-accepted theory among sleep researchers today is that sleep plays an important role in learning and memory by affecting mechanisms of synaptic plasticity. At the present time, there are two main competing views regarding how sleep a...
متن کاملVariable binding by synaptic strength change
Q1 Please confirm affiliation details. Q2 Please provide publisher location for the following references: Abeles (1991), Amit (1989), Anderson and Lebiere (1998), Churchland and Sejnowski (1992), Dayan and Abbott (2005), Filmore (1968), Hebb (1949), Hofstadter (1979), Hopcroft and Ullman (1979), Jackendoff (2002), Klatzky (1980), Maass and Bishop (2001), Malsburg (1986), Newell (1990), Rumelhar...
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ژورنال
عنوان ژورنال: Brain Research
سال: 2012
ISSN: 0006-8993
DOI: 10.1016/j.brainres.2012.05.061